extract of Glycyrrhiza glabra Linn. in aspirin induced ulcer in rats. . The aim of the study was to determine anti ulcer activity of stem bark of. Anti-ulcer activity was evaluated by measuring the ulcer index, gastric content, total Keywords: Anti-ulcer, Cold-restraint, Glycyrrhiza glabra, GutGardTM. The present research has been carried out to investigate antiulcer activity of ethanolic extract of Cynodon dactylon, Ocimum sanctum, Glycyrrhiza glabra, Ficus.
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National Center for Biotechnology InformationU.
The possibility of HEGG exerting a cytoprotective effect is indicated because it successfully prevents the formation of gastric lesions in the indomethacin and ethanol induced ulcer models. Stress is initiated by in cooperation of physiological and psychological factors. Assays of physical stability and antioxidant activity of a topical formulation added with different plant extracts. Ethanol-induced gastric ulcer According to the method of Cerqueira et al.
All the administrations were delivered with oral gavages via the aid of an orogastric cannula. In addition, some of these treatments may cause side effects like hypersensitivity, arrhythmia, weakness, and hematopoietic disorders 7. Y, M, et al. The animals were randomly assigned to different groups. The study was conducted on Swiss mice of either sex, weighing 25—30 g.
Ethanol and HCl are corrosive agents that damage the gastric mucosa. HEGG was evaluated for antiulcerogenic activity and acute toxicity profile in mice.
Thereby glycygrhiza was reported, G. In the present study, the HEGG protected the gastric mucosa of animals against stress-related injuries, confirming the gastroprotective effect of HEGG.
The findings that omeprazole and cimetidine orally protected the gastric mucosa against ethanol-induced and stress induced damage are in agreement with the works of other authors Experimental Extract preparation The plant G. The animals were euthanized and the stomachs were removed and opened along the greater curvature. The plant kingdom as a source of antiulcer remedies. Oral administration of absolute ethanol produced multiple mucosal lesions in the mice stomach.
The study was conducted using Omeprazole as the standard. Thirty minutes after the administration of ethanol, the mice were killed by cervical dislocation, and the stomach was removed and opened along the greater curvature. HEGG has antiulcer properties and significantly reduced the damage of gastric mucosa induced by indomethacin, suggesting that its gastroprotective effect involves the increase in the prostaglandin synthesis.
Omeprazole also significantly inhibited the ethanol-induced gastric lesion Modern trends in toxicology.
Anti-ulcer activity of aqueous and ethanolic extracts of Glycyrrhiza glabra L. in rats.
Find articles by Mostafa Mostafavi. The stomachs were gently rinsed with water to remove the gastric contents and blood clots, for subsequent examination. Find articles by Ghader Jalilzadeh-Amin. The gastric mucosa was examined for lesions with a binocular stereomicroscope Nikon SMZ It was observed that the hydroalcoholic extract of G.
The anti-gastroulcerative activity of beta-sitosterol-beta-d-glucoside and its aglycone in rats. Guidelines Upcoming Special Issues. The preventive effect was calculated by the method activityy Basile et al.
Recently it was shown that licorice in a combination product could heal ulcers effectively 33 that strongly confirm results of this study. According to Morrison et al.
Anti Ulcer Activity Of Aloevera And Glycyrrhiza Glabra In Swiss Albino Rats |
He is a GPAT qualified student and presented oral and poster presentation in national level seminars. Stress increases the formation of ROS, decreases the cell activitg rate, increases gastric juice secretion, and promotes inhibition of prostaglandin synthesis, leading to alterations in the circulating nitric oxide and the gastric mucosa Flavonoids-potent and versatile biologically glycyrrhizw compounds interacting with cytochromes P Gastric and duodenal peptic ulcers affect thousands of antiulceer and in the clinical practice are the most common gastrointestinal disorders.
The antioxidant properties of flavonoids and tannins have been related to anti-ulcer activity 31 since free radicals are developed in gastric mucosal lesions. Prophylactic and curative effects of Bacopa monniera in gastric ulcer models. Stomach was opened along the greater curvature then ulceration index was determined examining the inner lining of stomach.
Risk and safety assessment on the consumption of licorice root Glycyrrhiza sp. The peptic ulcer refers to chronic ulcerative disorder of the upper gastro-intestinal tract, which have a common participation of acid and pepsin in their pathogenesis.
All chemicals and extract doses were prepared immediately before use. The general signs of toxicity i. Ulcer index and preventive index of each of the groups was calculated using standard methods as described above.
Ulcer indices and preventive indices are shown in Table 3. Additionally, it was a potent antioxidant toward LDL oxidation in in-vitro and in-vivo studies.
It should be emphasized that the doses that displayed antiulcer activity are much lower than the LD The purpose and value of LD50 determinations.
Anti-ulcer properties of saponins have been reported A depletion of stomach wall mucus after oral ethanol administration has also been reported